Amlodipine besylate is an anti-hypertensive drug belong to the category calcium channels blocker. It is commonly used in treatment of hypertension and angina. Amlodipine besylate is pharmacologically very effective, but due to photosensitive nature it undergoes an easy degradation which affects on bioavailability of drug. The objective of present study was to stabilize amlodipine besylate from degradation by polymorphic modification. The system of amlodipine besylate was prepared by applying magnetic field with magnet of power 10000 Tesla for 1 h and by using methanol as solvent for crystallization. The prepared crystals were evaluated for degradation of amlodipine besylate up to 30 days by using titrimetric methodology, solubility, melting point and characterization by using X-ray diffraction pattern and differential scanning colorimetry. This attributes to the changes occurred in an arrangement of atoms during alignment at various environment. Consequently inter atomic and inter planner distance changes associated with crystallization results in enhanced resistance against the all sources of degradants. Some conformational changes occurred with the change of environment for crystallization of amlodipine besylate and the polymorphic changes are the reason of stabilization of amlodipine besylate from degradation.
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